My research interests focus on corporate finance. In particular, I am interested in international finance, behavioral finance, sovereign wealth funds, mergers and acquisitions and firm payout policy.
Cell Biology & Biophysics
My research focuses on the interactions between RNA viruses and their hosts. For successful replication, RNA viruses must avoid the many RNA degradation pathways that exist inside their host cells. One pathway in particular, nonsense-mediated decay (NMD) is a pathway designed to protect our cells from expressing potentially harmful proteins from faulty mRNA transcripts. Nearly one-third of all genetic diseases and cancers have been associated with nonsense mutations, making NMD an important pathway in human disease research. Viruses are also targeted by NMD and have likely evolved to circumvent this pathway. My current projects focus on how model plant RNA viruses evade the NMD pathway to support successful replication and I am also interested in identifying novel antiviral components of cellular RNA degradation pathways. This work has the potential to transform our understanding of virus-host interactions as well as provide a better understanding of the NMD pathway.
Cell Biology & Biophysics
The McGraw lab studies the molecular and cellular basis of embryonic development. We use the zebrafish as a model organism because the embryos develop independently from their mother and are optically transparent, making them amenable to live time-lapse imaging. Embryonic development requires the exquisite coordination of multiple cellular behaviors such as proliferation, migration, and differentiation. Collective cell migration, which is movement of cells as a cohesive group, is a critical process during embryonic organ formation, wound healing and is inappropriately co-opted during the invasion of certain cancers. By understanding how diverse populations of cells coordinate their behavior while also maintaining migratory behavior, we hope to elucidate the basic processes of organogenesis in the developing embryo and how these processes are dysregulated in some invasive cancers.
Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes is the fundamental cause of many ocular ischemic diseases, most solid cancers, and leukemia. Yet, molecular and biochemical mechanisms governing this fundamental processes remain poorly understood. Our long term goal is to use our experience in the HIF pathway and DNA/ histone demethylases to delineate their roles in normal development/ disease states, and identify small molecule modulators that can be used to develop more effective strategies for therapeutic intervention. Please note that for critical contributions on HIF pathway one of Dr Mukherji’s mentors, Sir Ratcliffe, received 2016 Lasker Award in Basic Medical Research. Dr Mukherji significantly contributed in 2 of the 5 key publications cited by the Lasker foundation.
My research interests focus on mineralogy, mineral chemistry, and geochemistry--why do minerals behave they way they do, or have certain properties. What do they tell us about the environment in which they formed--temperature, pressure, solution chemistry, etc. I am especially interested in ore minerals--metal sulfides and oxides--that formed by precipitation from hydrothermal solutions.
I am also interested in the characterization and conservation of architectural stone that has deteriorated--what are the alteration products, what processes caused the deterioration, and what are the products of the alteration?