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Johnson,Mark Oral and Craniofacial Sciences   My current research involves studying the interactions between muscle and bone and how this changes with aging. This involves understanding how estrogen hormones acting through their receptors regulated this crosstalk. I also have long-standing interests in the genetic basis of human diseases. My laboratory discovered the High Bone Mass mutation (G171V mutation in LRP5) that was critical to our understanding of the role of the Wnt/b-catenin signaling pathway in the regulation of bone mass and in bone's response to mechanical loading.