PROF, AST RESRCH - Saman Zeeshan
Saman Zeeshansaman.zeeshan@umkc.edu
Cancer is the second leading cause of death in U.S. Lung and Breast cancer are the leading cancers with adverse differences in cancer burden in the medically underrepresented population groups. Genomic differences between lung tumor populations can lead to differences in risk and response to treatment. We have previously reported histological and population differences in lung tumor biology with alternative splicing as a key driver of novel molecular biomarkers and neoantigens. In addition to providing insights into the role of splicing events as potential drivers of cancer, profiling of genomic signatures (gene expression and DNA variants) has also uncovered novel molecular biomarkers for the diagnosis, treatment, and prognosis of cancers. The multifaceted role of tumor antigens has furthered our understanding of population and histological differences in the biology underlying cancer and hold significant potential to aid in development of new therapeutic agents to mitigate cancer and cancer disparities. Our research revolves around understanding that race, ethnicity, genetic ancestry, and social determinants of health can impact biology, and trying to identify such differences is key to advancing health equity.
Jun 8, 2024
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