Project(s)

Rescue of TET2 Haploinsufficiency in Myelodysplastic Syndrome Patients (Ongoing)
Structure-Function Analysis of TET2 Mutations and Leukemia Progression (Ongoing)

Faculty Profile

https://pharmacy.umkc.edu/directory/mridul-mukherji/


Research Description

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Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes is the fundamental cause of many ocular ischemic diseases, most solid cancers, and leukemia. Yet, molecular and biochemical mechanisms governing this fundamental processes remain poorly understood. Our long term goal is to use our experience in the HIF pathway and DNA/ histone demethylases to delineate their roles in normal development/ disease states, and identify small molecule modulators that can be used to develop more effective strategies for therapeutic intervention. Please note that for critical contributions on HIF pathway one of Dr Mukherji’s mentors, Sir Ratcliffe, received 2016 Lasker Award in Basic Medical Research. Dr Mukherji significantly contributed in 2 of the 5 key publications cited by the Lasker foundation.


Afflicated Department(s)

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Pharmaceutical Sciences  

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