Faculty Profile
https://dentistry.umkc.edu/erin-ealba-bumann-lab/
Our experiments not only reveal that neural crest mesenchyme (NCM) autonomously regulates cell cycle progression and the timing of osteogenic differentiation, but they also indicate that cell cycle and osteogenesis are inexorably linked as a developmental module in vivo as they are in vitro. Our work also uncovered a novel function for bone resorption, which is to help establish species-specific jaw length; and our transplant experiments indicate that the underlying molecular mechanisms stem from the ability of NCM to control the activity of its own derivatives (i.e., osteocytes) and also that of mesoderm-derived osteoclasts. We show the remarkable ability of NCM to maintain spatiotemporal control over the induction, differentiation, deposition, mineralization, and the resorption of bone is what integrates the determinants of jaw length across multiple embryonic stages, and is what empowers NCM with its ability to generate skeletal variation during disease and evolution
no
I'd like to work with this faculty member. What should I do next?
Now that UR-Linked has helped you to identify a faculty member whose interests align with your interests, be sure to
review
the essential steps in contacting a potential faculty mentor .
The Director of Undergraduate Research,
Dr. Jane Greer. , can provide you with further guidance
about finding and connecting with faculty mentors at UMKC.
Once you have reviewed the essential steps to prepare for connecting with a potential faculty mentor, you
can use the "Contact Details" for this project to connect with the faculty member and to begin a conversation about
how you might work with that him or her.
