Project(s)

Bacterial Cell Wall Metabolomics (Ongoing)

Faculty Profile

https://kc-csrv-sopweb.kc.umkc.edu/faculty-staff/directory/william-gutheil/


Research Description

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My research is generally focused on bacterial cell wall biosynthesis, the effects of antibiotics on this process, mechanisms of resistance to antibiotics targeting this process, and the development of new agents targeting this process. Our research falls into the general areas of Biological Chemistry, Bio-Analytical Chemistry, and Bio-Organic Chemistry. We make heavy use of liquid chromatography-mass spectrometry using AB Sciex QTrap instruments. This is amazingly powerful technology, which is now foundational to pharmaceutical and life-sciences research. We are also using chemical library screening to identify new antibacterial agents using high throughput technology. Finally, we make novel bioactive molecules using chemical synthesis methods, and use computationally aided drug discovery program which are run on the University of Missouri's Lewis4 cluster, which is a 5000 cpu cluster.


Afflicated Department(s)

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Pharmaceutical Sciences  


Faculty-related Tags
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Analytical  Antibiotic  Biology  Chemistry  Computational  Drug Discovery  Microbiology  Resistance  Synthesis  

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