PROF, AST -
Erin Bumann DDS PhD MS
Dr. Bumann’s innovative research involving avian embryos has focused on cells that influence bone development, in hopes of someday preventing or reducing craniofacial abnormalities in people. She also emphasizes mentoring the undergraduate, graduate and fellowship members of her research team.
The lab has identified multiple developmental mechanisms that control the size and shape of the jaw skeleton. Our experiments not only reveal that neural crest mesenchyme (NCM) autonomously regulates cell cycle progression and the timing of osteogenic differentiation, but they also indicate that cell cycle and osteogenesis are inexorably linked as a developmental module in vivo as they are in vitro. Our work also uncovered a novel function for bone resorption, which is to help establish species-specific jaw length; and our transplant experiments indicate that the underlying molecular mechanisms stem from the ability of NCM to control the activity of its own derivatives (i.e., osteocytes) and also that of mesoderm-derived osteoclasts. We show the remarkable ability of NCM to maintain spatiotemporal control over the induction, differentiation, deposition, mineralization, and the resorption of bone is what integrates the determinants of jaw length across multiple embryonic stages, and is what empowers NCM with its ability to generate skeletal variation during disease and evolution.
School of Dentistry
We are currently looking for undergraduates to join the lab!
Oct 24, 2019
I'm interested in this project. What should I do next?
Now that UR-Linked has helped you to identify a faculty project that interests you and for which you might be
qualified, be sure to review
the essential steps in contacting a potential faculty mentor
The Director of Undergraduate Research,
Dr. Jane Greer.
, can provide you with further guidance about finding
and connecting with faculty mentors at UMKC.
Once you have reviewed the essential steps to prepare for connecting
with a potential faculty mentor, you can use the "Contact Details" for this project to connect with the faculty
member and to begin a conversation about how you might get involved.